Intravitreal chemotherapy for retinoblastoma has revolutionized treatment of this pediatric cancer. Fear of spreading the cancer extraocularly once kept physicians from attempting intravitreal treatments. But with further research and advances in technology, the procedure has gone from taboo to routine. Eyes once thought doomed to enucleation are now salvaged. Still, care must be taken to ensure safety. In this interview from AAO 2014, Dr. Brian Marr shares his technique in detail. Dr. Marr has treated about 300 patients with no incidence of metastasis outside the eye.